Annexin A1 is upregulated in p53-positive gastric cancer
نویسندگان
چکیده
منابع مشابه
Upregulated expression of Annexin II is a prognostic marker for patients with gastric cancer
BACKGROUND The role of annexin II in the development and progression of gastric cancer was explored. METHODS Real-time PCR was conducted to detect annexin II and S100A6 mRNA expression. Protein expressions of annexin II and S100A6 were also examined by immunohistochemistry in 436 clinicopathologically characterized gastric cancer cases. RESULTS The expression of annexin II and S100A6 mRNA d...
متن کاملFra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer.
Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Fra-1 (FOSL1) plays important roles in oncogenesis in various malignancies. We investigated the expression of Fra-1 in gastric cancer (GC) tissues by qPCR, immunohistochemistry (IHC) and western blot technologies. The results showed that Fra-1 was overexpressed in gastric cancer tissues compared w...
متن کاملClinical Significance of Annexin A1 Expression in Breast Cancer
PURPOSE The expression of Annexin A1 (ANXA1) is known to be reduced in human breast cancer; however, the role of ANXA1 expression in the development of breast cancer remains unclear. In this study, we determined the relationship between the expression features of ANXA1 and the prognostic factors of breast cancer. METHODS Human breast tissues were obtained from patients specimens who had under...
متن کاملAnnexin A1 Is Increased in the Plasma of Preeclamptic Women
BACKGROUND Preeclampsia (PE) is a pregnancy disease associated with exacerbated inflammatory response. Annexin A1 (AnxA1) is a glucocorticoid-regulated protein endowed with anti-inflammatory and proresolving properties that has been much studied in various animal models of inflammation but poorly studied in the context of human inflammatory diseases. The main objective of this study was to meas...
متن کاملAnnexin A1 attenuates EMT and metastatic potential in breast cancer
Metastasis is the major cause of carcinoma-induced death, but mechanisms involved are poorly understood. Metastasis crucially involves epithelial-to-mesenchymal transition (EMT), causing loss of epithelial polarity. Here we identify Annexin A1 (AnxA1), a protein with important functions in intracellular vesicle trafficking, as an efficient suppressor of EMT and metastasis in breast cancer. AnxA...
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ژورنال
عنوان ژورنال: Annals of Cancer Research and Therapy
سال: 2018
ISSN: 1344-6835,1880-5469
DOI: 10.4993/acrt.26.26